Micronuclei levels in nanocomposites production workers: Interpretation of results from two years of monitoring

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F19%3A10409646" target="_blank" >RIV/00064165:_____/19:10409646 - isvavai.cz</a>

Alternative codes found

RIV/67985858:_____/19:00522981 RIV/68378041:_____/19:00522981 RIV/00216208:11110/19:10409646 RIV/46747885:24210/19:00008850

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Micronuclei levels in nanocomposites production workers: Interpretation of results from two years of monitoring

Original language description

Micronucleus assay, which has been used for almost sixty years, is one of the basic methodological approaches of genetic toxicology. This is also evident from more than 10,500 references found in PubMed database. These studies concern the evaluation of cytotoxicity and genotoxicity of numerous chemicals and in the last decade also nanomaterials (NM) and nanoparticles (NP). Surprisingly, no relevant human studies focused on MN formation following the exposure to NP have been reported. In our study we analyzed 4x (in September 2016 and 2017; pre-shift and post-shift each year) samples in a group of workers, working for almost 18 years in nanocomposites research, and matched controls. Detail aerosol exposure monitoring of particulate matter (PM) including nano-sized fractions was completed during working shift in a sampling day. The micronucleus assay using Pan-Centromeric Chromosome Paint was applied to recognize, beside the frequency of total micronuclei (MN) in binucleated cells (BNC), also other types of chromosomal damage (losses and breaks), including the centromere positive (CEN+) and centromere negative (CEN-) micronuclei. The monitoring data showed differences in the risk of exposure to NP related to individual working processes, as well as differences in chemical composition of nano-fraction. Cytogenetic results demonstrated consistently (both years): (i) possible adaptation to long-term exposure of NP (related to total frequency of MN), (ii) short-term (2.5 h) exposure could be a reason for the aberration increase, particularly a chromosomal losses (aneugenic effect).

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2018 - Conference Proceedings, 10th Anniversary International Conference on Nanomaterials - Research and Application

ISBN

978-80-87294-89-5

ISSN

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e-ISSN

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Number of pages

6

Pages from-to

554-559

Publisher name

Tanger

Place of publication

Ostrava

Event location

Brno

Event date

Oct 17, 2018

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000513131900096