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In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F20%3A10412603" target="_blank" >RIV/00064165:_____/20:10412603 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WaZfK-LQTO" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WaZfK-LQTO</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ahj.2020.04.004" target="_blank" >10.1016/j.ahj.2020.04.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events

  • Original language description

    Background: In patients with stable coronary heart disease, it is not known whether achievement of standard of care (SOC) targets in addition to evidence-based medicine (EBM) is associated with lower major adverse cardiovascular events (MACE): cardiovascular death, myocardial infarction, and stroke. Methods: EBM use was recommended in the STabilisation of Atherosclerotic plaque By Initiation of darapLadIb TherapY trial. SOC targets were blood pressure (BP) &lt;140/90 mm Hg and low-density lipoprotein-cholesterol (LDL-C) &lt;100 mg/dL and &lt;70 mg/dL. In patients with diabetes, glycosylated hemoglobin A1c (HbA1c) &lt; 7% and BP of &lt;130/80 mm Hg were recommended. Feedback to investigators about rates of EBM and SOC was provided regularly. Results: In 13,623 patients, 1-year landmark analysis assessed the association between EBM, SOC targets, and MACE during follow-up of 2.7 years (median) after adjustment in a Cox proportional hazards model. At 1 year, aspirin was prescribed in 92.5% of patients, statins in 97.2%, β-blockers in 79.0%, and angiotensin-converting enzyme inhibitors/angiotensin-II receptor blockers in 76.9%. MACE was lower with LDL-C &lt; 100 mg/dL (70-99 mg/dL) compared with LDL-C &gt;= 100 mg/dL (hazard ratio [HR] 0.694, 95% CI 0.594-0.811) and lower with LDL-C &lt; 70 mg/dL compared with LDL-C &lt; 100 mg/dL (70-99 mg/dL) (HR 0.834, 95% CI 0.708-0.983). MACE was lower with HbA1c &lt; 7% compared with HbA1c &gt;= 7% (HR 0.705, 95% CI 0.573-0.866). There was no effect of BP targets on MACE. Conclusions: MACE was lower with LDL-C &lt; 100 mg/dL (70-99 mg/dL) and even lower with LDL-C &lt; 70 mg/dL. MACE in patients with diabetes was lower with HbA1c &lt; 7%. Achievement of targets is associated with improved patient outcomes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    American Heart Journal

  • ISSN

    0002-8703

  • e-ISSN

  • Volume of the periodical

    225

  • Issue of the periodical within the volume

    July

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    97-107

  • UT code for WoS article

    000541737100013

  • EID of the result in the Scopus database

    2-s2.0-85085290726