Cerebellum - aging of the neuronal machine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F21%3A10451418" target="_blank" >RIV/00064165:_____/21:10451418 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10451418
Result on the web
<a href="https://doi.org/10.1016/B978-0-12-817990-1.00025-1" target="_blank" >https://doi.org/10.1016/B978-0-12-817990-1.00025-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-817990-1.00025-1" target="_blank" >10.1016/B978-0-12-817990-1.00025-1</a>
Alternative languages
Result language
angličtina
Original language name
Cerebellum - aging of the neuronal machine
Original language description
This chapter provides an overview of the structure of the cerebellum, the current concepts of the cerebellar function, and its decline associated with aging-from macrostructural, functional, histological, biochemical, and epigenetic perspectives. Several candidate hypotheses are discussed to explain the seemingly contradictory lower epigenetic age of the cerebellum relative to the rest of the brain, but also a rate of atrophy far higher than seen in other parts of the brain with the exception of hippocampus and prefrontal cortex, with both structural damage to cerebellar white matter and loss of cerebellar neurons. The cerebellum is hypothesized to create new neural scaffolds to counteract aging-related changes and maintain its performance. If sufficient informational input is provided as in simpler motor tasks, while signal noise due to white matter affections in complex, extensive cognitive networks do not allow for the construction and utilization of cerebellar internal models, leading ultimately to the failure of cerebellar feedforward processing stream.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet
ISBN
978-0-12-817990-1
Number of pages of the result
8
Pages from-to
281-288
Number of pages of the book
659
Publisher name
Elsevier
Place of publication
London
UT code for WoS chapter
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