The DNA methylome of cervical cells can predict the presence of ovarian cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10440189" target="_blank" >RIV/00064165:_____/22:10440189 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10440189 RIV/00064211:_____/22:W0000036
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JCeOrkcwds" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JCeOrkcwds</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-021-26615-y" target="_blank" >10.1038/s41467-021-26615-y</a>
Alternative languages
Result language
angličtina
Original language name
The DNA methylome of cervical cells can predict the presence of ovarian cancer
Original language description
The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Mullerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Mullerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as the Women's risk IDentification for Ovarian Cancer index or WID-OC-index) is capable of identifying women with an ovarian cancer in the absence of tumour DNA with an AUC of 0.76 and women with an endometrial cancer with an AUC of 0.81. This and the observation that the cervical cell WID-OC-index mimics the epigenetic program of those cells at risk of becoming cancerous in BRCA1/2 germline mutation carriers (i.e. mammary epithelium, fallopian tube fimbriae, prostate) further suggest that the epigenetic misprogramming of cervical cells is an indicator for cancer predisposition. This concept has the potential to advance the field of risk-stratified cancer screening and prevention.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications [online]
ISSN
2041-1723
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
448
UT code for WoS article
000749535300011
EID of the result in the Scopus database
2-s2.0-85124059498