Adherence and blood pressure control in patients with primary aldosteronism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10443214" target="_blank" >RIV/00064165:_____/22:10443214 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/22:43923496 RIV/00216208:11110/22:10443214 RIV/00216208:11120/22:43923496

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rHCperz6HQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rHCperz6HQ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/08037051.2022.2061416" target="_blank" >10.1080/08037051.2022.2061416</a>

Result language

angličtina

Original language name

Adherence and blood pressure control in patients with primary aldosteronism

Original language description

PURPOSE: The aim of our study was to evaluate the adherence to mineralocorticoid receptor (MR) antagonists and other antihypertensive therapy and blood pressure control in conservatively treated patients with primary aldosteronism (PA). MATERIALS AND METHODS: Conservatively treated subjects with previously confirmed PA (n-50, 64.5 +- 9 years of age, 24% women) were investigated via our outpatient hypertension clinic. All subjects underwent regular examinations in our clinic. In addition to basic laboratory and clinical parameters, 24 h ambulatory blood pressure monitoring (ABPM) (Spacelabs) was evaluated. Unplanned blood sampling for assessment of serum antihypertensive drug concentrations by the means of liquid chromatography-mass spectrometry was performed in all patients. In case of spironolactone, its active metabolite canrenone was also evaluated. Total non-compliance was then defined as the absence of all measured antihypertensive drugs. Partial non-compliance was calculated as the absence of serum levels of at least one, but not all antihypertensive drugs prescribed. RESULTS: Good blood pressure control was detected (mean 24 h systolic/diastolic BP 130 +- 12/77 +- 9 mmHg). The average number of antihypertensive drugs was 3.9 +- 1.5. All subjects were treated by MR antagonists. 44% of patients received spironolactone (average daily dose 45 +- 20 mg) and in the remaining 56% of subjects eplerenone was administered (average daily dose 80 +- 30 mg) due to spironolactone side effects. Assessment of antihypertensive drug concentrations revealed full adherence in 80% of all subjects, partial nonadherence was noted in the remaining 20% of subjects. MR antagonist levels were detected in almost all subjects (49 out of 50). CONCLUSIONS: Good blood pressure control and adherence to therapy were detected in conservatively treated patients with PA. Eplerenone had to be used quite often as male subjects did not tolerate dose escalation due to spironolactone side effects.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood Pressure

ISSN

0803-7051

e-ISSN

1651-1999

Volume of the periodical

31

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

58-63

UT code for WoS article

000783727800001

EID of the result in the Scopus database

2-s2.0-85128449106