Bridging structural and functional biomarkers in functional movement disorder using network mapping

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10444064" target="_blank" >RIV/00064165:_____/22:10444064 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/22:00076136 RIV/00216208:11110/22:10444064 RIV/00216224:14110/22:00125676

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n5eurlQnFs" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n5eurlQnFs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/brb3.2576" target="_blank" >10.1002/brb3.2576</a>

Result language

angličtina

Original language name

Bridging structural and functional biomarkers in functional movement disorder using network mapping

Original language description

Background: There are gaps in our neurobiological understanding of functional movement disorder (FMD). Objectives: We investigated gray matter volumetric profiles in FMD, and related findings to resting-state functional connectivity (rsFC) profiles using Human Connectome Project data. Methods: Volumetric differences between 53 FMD patients and 50 controls were examined, as well as relationships between individual differences in FMD symptom severity and volumetric profiles. Atrophy network mapping was also used to probe whether FMD-related structural alterations preferentially impacted brain areas with dense rsFC. Results: Compared to controls without neurological comorbidities (albeit with mild depression and anxiety as a group), the FMD cohort did not show any volumetric differences. Across patients with FMD, individual differences in symptom severity negatively correlated with right supramarginal and bilateral superior temporal gyri volumes. These findings remained significant adjusting for FMD subtype or antidepressant use, but did not remain statistically significant adjusting for depression and anxiety scores. Symptom severity-related structural alterations mapped onto regions with dense rsFC-identifying several disease epicenters in default mode, ventral attention, and salience networks. Conclusions: This study supports that FMD is a multinetwork disorder with an important role for the temporoparietal junction and its related connectivity in the pathophysiology of this condition. More research is needed to explore the intersection of functional neurological symptoms and mood.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NU20-04-00332" target="_blank" >NU20-04-00332: Organic and functional comorbidities in functional movement disorders, common pathophysiological mechanisms, biomarkers and prognostic factors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain and Behavior

ISSN

2162-3279

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

e2576

UT code for WoS article

000782842400001

EID of the result in the Scopus database

2-s2.0-85128238451