Symptomatic preterm infants suffer from lung function deficits, regardless of bronchopulmonary dysplasia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10447001" target="_blank" >RIV/00064165:_____/22:10447001 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10447001 RIV/00216208:11110/22:10447001 RIV/00216208:11130/22:10447001
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vhVYcirPlh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vhVYcirPlh</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ppul.26144" target="_blank" >10.1002/ppul.26144</a>
Alternative languages
Result language
angličtina
Original language name
Symptomatic preterm infants suffer from lung function deficits, regardless of bronchopulmonary dysplasia
Original language description
BACKGROUND: The long-term respiratory consequences for children with bronchopulmonary dysplasia (BPD) are well known. However, there is little emphasis on monitoring preterm infants without BPD. Few studies have explored the lung function status of infants with the symptoms of chronic lung disease of prematurity (CLD). OBJECTIVE: To evaluate functional lung deficits in preterm infants with CLD, and to assess the perinatal determinants of diminished lung function. METHODS: In our cross-sectional study, 132 preterm infants with symptomatic CLD underwent infant pulmonary function testing (iPFT) at a median post-term age of 0.9 years. The iPFT included bodypletysmography, compliance measurement, tidal breath analysis, and rapid thoracoabdominal compression. The relationships between the respective z scores of the iPFT parameters to perinatal characteristics, postnatal treatment, and BPD status were investigated. RESULTS: 73 patients (55.3%) were born before the 28(th) week of gestation, and 92 (69.7%) met the BPD criteria. Functional deficits were detected in 85.8%. The obstructive ventilatory pattern was more prevalent than restrictive (36.3 vs 12.4%, p < 0.001). Infants with restriction had lower birth weight and required a longer duration of oxygenotherapy. In a univariate model, the lung function correlated with the duration of invasive mechanical ventilation, gestational week, and birth weight. In a general linear model, BPD status was not an additional determinant of the iPFT results. CONCLUSION: IPFT may reveal significant functional deficits in preterm infants with CLD even without BPD. The current symptoms and perinatal factors may be more important determinants of functional deficits than the BPD status itself.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Pulmonology [online]
ISSN
1099-0496
e-ISSN
1099-0496
Volume of the periodical
57
Issue of the periodical within the volume
12
Country of publishing house
BD - BANGLADESH
Number of pages
10
Pages from-to
3119-3128
UT code for WoS article
000860945900001
EID of the result in the Scopus database
2-s2.0-85138682351