Toxocara canis infection worsens the course of experimental autoimmune encephalomyelitis in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F22%3A10448706" target="_blank" >RIV/00064165:_____/22:10448706 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10448706 RIV/00216208:11310/22:10448706

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vmbwe1UO9f" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vmbwe1UO9f</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0031182022001238" target="_blank" >10.1017/S0031182022001238</a>

Result language

angličtina

Original language name

Toxocara canis infection worsens the course of experimental autoimmune encephalomyelitis in mice

Original language description

Toxocara canis, a gastrointestinal parasite of canids, is also highly prevalent in many paratenic hosts, such as mice and humans. As with many other helminths, the infection is associated with immunomodulatory effects, which could affect other inflammatory conditions including autoimmune and allergic diseases. Here, we investigated the effect of T. canis infection on the course of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Mice infected with 2 doses of 100 T. canis L3 larvae 5 weeks prior to EAE induction (the Tc+EAE group) showed higher EAE clinical scores and greater weight loss compared to the non-infected group with induced EAE (the EAE group). Elevated concentrations of all measured serum cytokines (IL-1 alpha, IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma and TNF-alpha) were observed in the Tc+EAE group compared to the EAE group. In the CNS, the similar number of regulatory T cells (Tregs; CD4+FoxP3+Helios+) but their decreased proportion from total CD4+ cells was found in the Tc+EAE group compared to the EAE group. This could indicate that the group Tc+EAE harboured significantly more CD4+ T cells of non-Treg phenotype within the affected CNS. Altogether, our results demonstrate that infection of mice with T. canis worsens the course of subsequently induced EAE. Further studies are, therefore, urgently needed to reveal the underlying pathological mechanisms and to investigate possible risks for the human population, in which exposure to T. canis is frequent.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasitology

ISSN

0031-1820

e-ISSN

1469-8161

Volume of the periodical

149

Issue of the periodical within the volume

13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1720-1728

UT code for WoS article

000863785300001

EID of the result in the Scopus database

2-s2.0-85138176798