Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F23%3A10467717" target="_blank" >RIV/00064165:_____/23:10467717 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10467717

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7Q2DsOp1w" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=D7Q2DsOp1w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers15164045" target="_blank" >10.3390/cancers15164045</a>

Result language

angličtina

Original language name

Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore

Original language description

This study aims to compare the performance of the standardized consensus Immunoscore (IS) digital pathology assay to an evaluation of the immune response via visual examination of hematoxylin-eosin (H&amp;E) slides and CD3+/CD8+ stained slides, achieved by expert pathologists. Herein, we report the evaluation of 540 stained images by multi-institutional pathologists to determine the concordance between pathologist assessment before and after training. The results show that the IS assay outperformed expert pathologists&apos; T-score evaluation in the clinical setting. This reveals the potential of the IS as an immune pathology tool, critical for reproducible quantitative analysis of tumor-infiltrated immune cells. These findings can contribute to a better diagnosis, allowing one to stratify cancer patients into reliable prognostic groups, based on the immune parameters quantified by IS. This work will likely impact the management of colon cancer patients as it raises the importance of the implementation of digital pathology in cancer diagnosis to provide appropriate personalized therapeutic decisions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

2072-6694

Volume of the periodical

15

Issue of the periodical within the volume

16

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

4045

UT code for WoS article

001057620800001

EID of the result in the Scopus database

2-s2.0-85168873201