Expanding options of supportive care in IgA nephropathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F23%3A10473493" target="_blank" >RIV/00064165:_____/23:10473493 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10473493
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4T2GohRe_c" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4T2GohRe_c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ckj/sfad201" target="_blank" >10.1093/ckj/sfad201</a>
Alternative languages
Result language
angličtina
Original language name
Expanding options of supportive care in IgA nephropathy
Original language description
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with a potentially serious prognosis. At present, management of IgAN is primarily based on therapeutic lifestyle changes, and excellent blood pressure control and maximized supportive treatment with the combination of inhibition of the renin-angiotensin-aldosterone system with either inhibitors of angiotensin-converting enzyme or angiotensin II receptor blockers and inhibitors of sodium-glucose cotransporter-2, and possibly in the future also with endothelin antagonists. Supportive care currently represents the cornerstone of treatment of IgAN. Targeted-release formulation of budesonide should replace systemic corticosteroids in patients with higher proteinuria and active histological lesions.New treatment options are aimed at immunopathogenesis of IgAN including depletion or modulation of Galactose-deficient-Immunoglobulin A1-producing B cells, plasma cells, and the alternate and/or lectin pathway of complement. The exact place of monoclonal antibodies and complement inhibitors will need to be determined.<br />This article reviews potential supportive therapies currently available for patients with IgAN.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Kidney Journal
ISSN
2048-8505
e-ISSN
2048-8513
Volume of the periodical
16
Issue of the periodical within the volume
Suppl 2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
"ii47"-"ii54"
UT code for WoS article
001124368000006
EID of the result in the Scopus database
2-s2.0-85179833171