Effect of Intraarrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Invasive Treatment : A Post Hoc Bayesian Reanalysis of a Randomized Clinical Trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F24%3A10479898" target="_blank" >RIV/00064165:_____/24:10479898 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10479898 RIV/00216208:11320/24:10479898
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cGWolPDD7m" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=cGWolPDD7m</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chest.2023.07.030" target="_blank" >10.1016/j.chest.2023.07.030</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Intraarrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Invasive Treatment : A Post Hoc Bayesian Reanalysis of a Randomized Clinical Trial
Original language description
Evidence for the effect of extracorporeal cardiopulmonary resuscitation (ECPR) from randomized controlled trials (RCTs) on survival with a favorable neurologic outcome is inconclusive. The Prague Out-of-Hospital Cardial Arrest study was an RCT evaluating the use of an invasive strategy, including early intraarrest transport, ECPR, and immediate invasive management to standard resuscitation in refractory out-of-hospital cardiac arrest. The study enrolled 256 patients with a median age of 58 years, 83% were men, and the median time of resuscitation was 52.5 min. The primary outcome of 180 days' survival with a favorable neurologic outcome (cerebral performance category 1 or 2) was reached in 31.5% of patients in the invasive strategy group and 22.0% of patients in the standard resuscitation strategy group (OR, 1.63; 95% CI, 0.93-2.85; absolute difference, 9.5%; 95% CI, -1.3% to 20.1%; P = .09). This difference was not statistically significant using the frequentist approach, and the primary outcome result was interpreted as neutral. An unreasonable, simplistic, yet common, practice is to label a trial as either positive or negative based on a difference in the primary outcome evaluated by a P value threshold of .05. Bayesian analysis may provide a comprehensive view of the data, especially when the benefits of an intervention are uncertain. Therefore, we performed a previously unplanned Bayesian reanalysis of the prespecified primary outcome while adhering to the intention to treat principle.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30221 - Critical care medicine and Emergency medicine
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chest
ISSN
0012-3692
e-ISSN
1931-3543
Volume of the periodical
165
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
368-370
UT code for WoS article
001171810100001
EID of the result in the Scopus database
2-s2.0-85174687454