Surgical results in patients with CNS lymphoma. Comparison of predictive value of intraoperative MRI and intraoperative histological examination for diagnostic biopsy yield

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F24%3A10488666" target="_blank" >RIV/00064165:_____/24:10488666 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/24:00001404 RIV/00216208:11110/24:10488666 RIV/00216208:11510/24:10488666

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=~0.IUu9h_9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=~0.IUu9h_9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bas.2024.103926" target="_blank" >10.1016/j.bas.2024.103926</a>

Result language

angličtina

Original language name

Surgical results in patients with CNS lymphoma. Comparison of predictive value of intraoperative MRI and intraoperative histological examination for diagnostic biopsy yield

Original language description

Introduction: Central nervous system lymphoma poses significant diagnostic challenges, with stereotactic biopsy being the gold standard for diagnosis. Intraoperative magnetic resonance imaging and intraoperative histological examination are utilized to enhance biopsy yield, yet their comparative efficacy remains unclear. Research question: This study aims to compare the diagnostic yield of intraoperative magnetic resonance imaging and intraoperative histological examination in stereotactic brain biopsies for central nervous system lymphoma. Materials and methods: A retrospective analysis was conducted on 115 patients who underwent stereotactic brain biopsies for central nervous system lymphoma. Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of intraoperative magnetic resonance imaging and intraoperative histological examination were assessed and compared. Results: Out of 125 surgeries, frameless biopsies were the most common, accounting for 74.4 percent. Intraoperative magnetic resonance imaging demonstrated a sensitivity of 80.00 percent and a specificity of 98.51 percent (AUC = 0.893, p = 0.004), whereas intraoperative histological examination showed a sensitivity of 66.67 percent and a specificity of 59.09 percent (AUC = 0.629, p = 0.459). Discussion and conclusions: The study emphasizes the critical role of intraoperative examinations, thus improving precision and diagnostic yield in the surgical management of central nervous system lymphoma. Intraoperative magnetic resonance imaging outperforms intraoperative histological examination in terms of sensitivity and specificity for confirming positive biopsy yields in central nervous system lymphoma, thereby reducing the need for additional surgeries. These findings support the routine use of intraoperative magnetic resonance imaging in the surgical strategy for central nervous system lymphoma to improve diagnostic accuracy and patient outcomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain and Spine

ISSN

2772-5294

e-ISSN

2772-5294

Volume of the periodical

4

Issue of the periodical within the volume

October

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

103926

UT code for WoS article

001348750100001

EID of the result in the Scopus database

2-s2.0-85207638495