Disease course after pregnancy in women with progressive multiple sclerosis symptoms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10503569" target="_blank" >RIV/00064165:_____/25:10503569 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10503569

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3CPIZlkuJd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3CPIZlkuJd</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/13524585251368248" target="_blank" >10.1177/13524585251368248</a>

Result language

angličtina

Original language name

Disease course after pregnancy in women with progressive multiple sclerosis symptoms

Original language description

Background: The impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS).Methods: This multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and compared to those of propensity score-matched women with progressive MS without a pregnancy history.Results: In total, 138 women with 164 pregnancies were included in the study, comprising 75 women with PPMS and 63 with SPMS. Of these, 24 women with PPMS and 47 with SPMS had longitudinal peri-pregnancy EDSS assessments and were included in the analysis of disability scores. A history of pregnancy was not associated with a significant difference in long-term disability trajectories in women with either PPMS (estimate = -0.02; 95% confidence interval (CI) = -0.07 to 0.04) or SPMS (estimate = 0.00; 95% CI = -0.02 to 0.03).Conclusion: A history of pregnancy is not associated with a significant difference in long-term disability in women with progressive MS symptoms.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multiple Sclerosis Journal

ISSN

1352-4585

e-ISSN

1477-0970

Volume of the periodical

31

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

1439-1451

UT code for WoS article

001574809600001

EID of the result in the Scopus database

2-s2.0-105019625123