Non-Contrast Radiation-Free NIR Lung Imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10506004" target="_blank" >RIV/00064165:_____/25:10506004 - isvavai.cz</a>
Alternative codes found
RIV/48135445:_____/25:N0000038
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dF8wiEkMTU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dF8wiEkMTU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines13112757" target="_blank" >10.3390/biomedicines13112757</a>
Alternative languages
Result language
angličtina
Original language name
Non-Contrast Radiation-Free NIR Lung Imaging
Original language description
Background/Objectives: Early localization of solitary pulmonary nodules (SPNs) remains challenging despite technological advances in endoscopic navigation, as the procedure often necessitates multiple ionizing imaging examinations. This study aimed to develop and evaluate a radiation-free optical method for SPN localization based on near-infrared (NIR) translumination. Methods: A miniaturized NIR light source was introduced into the bronchial tree to illuminate the lung parenchyma. The transmitted and scattered NIR light was detected in real time from the pleural side using minipleuroscopy and a CMOS camera. The approach exploits intrinsic differences in optical absorption and scattering between normal and pathological lung tissue, allowing visualization of the parenchymal micro-architecture without exogenous contrast agents. Results: In ex vivo porcine lungs, tissue structures were clearly visualized through up to approximately 4 cm of parenchyma. In a ventilated pig (n = 1), bronchial NIR illumination was consistently detected from the pleural cavity and produced distinct images of lobular structures and the bronchial mucosa. Conclusions: These feasibility findings demonstrate that NIR translumination can provide radiation-free intra-thoracic visualization and may serve as a valuable adjunct for biopsy guidance. Further quantitative validation and clinical translation are warranted to establish its applicability in human pulmonary procedures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
13
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
2757
UT code for WoS article
001624058300001
EID of the result in the Scopus database
2-s2.0-105023069736