Prognostic Value of Hematologic Indices and Composite Models in Anal Squamous Cell Carcinoma Treated with Image-Guided Chemoradiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F25%3A10506803" target="_blank" >RIV/00064165:_____/25:10506803 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10506803
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJMxJJExPT" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJMxJJExPT</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers17233838" target="_blank" >10.3390/cancers17233838</a>
Alternative languages
Result language
angličtina
Original language name
Prognostic Value of Hematologic Indices and Composite Models in Anal Squamous Cell Carcinoma Treated with Image-Guided Chemoradiotherapy
Original language description
Background: Anal squamous cell carcinoma (ASCC) is a rare malignancy primarily treated with chemoradiotherapy (CRT). This study evaluated outcomes and the prognostic value of simple hematologic indices in patients receiving modern image-guided CRT. Methods: Fifty-five patients with non-metastatic ASCC treated between 2017 and 2025 were retrospectively analyzed. Survival was estimated by Kaplan-Meier methods, and prognostic factors were assessed by log-rank testing and Cox regression. Baseline neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios were analyzed individually and in combination with nodal status. Results: At a median follow-up of 53.1 months, overall survival reached 90% at 5 years, whereas disease-free survival declined to 51%. Nodal positivity showed a non-significant trend toward poorer DFS. Baseline PLR >= 150 was significantly associated with inferior DFS in univariable analysis (HR 5.28, 95% CI 1.12-24.97, p = 0.036), while NLR >= 3 showed a borderline effect (p = 0.108). In multivariable models, PLR retained borderline prognostic relevance (p = 0.083), whereas Kaplan-Meier curves indicated non-significant trends (p = 0.129 and 0.055). Integrated models combining nodal status with PLR +/- NLR improved risk discrimination: Model A (N + PLR >= 150 +/- NLR >= 3) showed a trend (p = 0.059), and Model B (N + PLR >= 150) reached significance (p = 0.021; C-index approximate to 0.68-0.69). Conclusions: Modern CRT achieved excellent OS with acceptable toxicity, though early recurrences limited DFS. Integrating hematologic indices with nodal status provides a pragmatic, cost-effective approach for individualized risk assessment and follow-up in ASCC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancers
ISSN
2072-6694
e-ISSN
2072-6694
Volume of the periodical
17
Issue of the periodical within the volume
23
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
3838
UT code for WoS article
001634233700001
EID of the result in the Scopus database
2-s2.0-105024484611