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Recovery of mucosal-associated invariant T cells after myeloablative chemotherapy and autologous peripheral blood stem cell transplantation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F16%3AN0000122" target="_blank" >RIV/00064173:_____/16:N0000122 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/16:43910304

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s10238-015-0384-z" target="_blank" >http://dx.doi.org/10.1007/s10238-015-0384-z</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10238-015-0384-z" target="_blank" >10.1007/s10238-015-0384-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Recovery of mucosal-associated invariant T cells after myeloablative chemotherapy and autologous peripheral blood stem cell transplantation

  • Original language description

    Immune reconstitution after high-dose chemotherapy and stem cell transplantation plays a key role in restoring immunocompetence including defense against infection, immune regulation, and onco-immune surveillance. In this work, we examined the recovery of mucosal-associated invariant T (MAIT) cells, recently discovered innate-like T cells, after various types of myeloablative chemotherapy and autologous peripheral blood stem cell transplantation in 29 patients. We show that MAIT cells are relatively resistant to myeloablative conditioning. The median amount of MAIT cells rises to 43 % around day +30 and is sustained through further measurements on days +60 and +100. Moreover, MAIT cell recovery reaches 100 % of pre-treatment values in 33 % of patients already by day +60. The only factor affecting recovery of MAIT cells is age, younger age being associated with earlier MAIT cell recovery. The pre-treatment quantity of MAIT cells carries a prognostic impact on the early post-transplantation course. Patients with high levels of MAIT cells pre-treatment have significantly lower peak CRP levels (79.45 vs. 150 mg/L) post-treatment, reflecting a clinical trend of less severe infectious complications (less febrile days and less days on intravenous antibiotics). Altogether these data suggest that a high proportion of MAIT cells survive myeloablative chemotherapy and maintain their capacity to fight against infections probably on mucosal surfaces.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Medicine

  • ISSN

    1591-8890

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    IT - ITALY

  • Number of pages

    9

  • Pages from-to

    529-537

  • UT code for WoS article

    000386361400006

  • EID of the result in the Scopus database

    2-s2.0-84944598810