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Ginkgo biloba extract EGb 761(R) versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F18%3AN0000188" target="_blank" >RIV/00064173:_____/18:N0000188 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/18:43916712

  • Result on the web

    <a href="https://doi.org/10.1007/s11096-018-0654-4" target="_blank" >https://doi.org/10.1007/s11096-018-0654-4</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11096-018-0654-4" target="_blank" >10.1007/s11096-018-0654-4</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ginkgo biloba extract EGb 761(R) versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial

  • Original language description

    Background Ginkgo biloba extract EGb 761 (R) and pentoxifylline are frequently prescribed for the treatment of tinnitus. Objective To compare the treatment effects of Ginkgo biloba extract EGb 761R and pentoxifylline. Setting The study was performed at Department of Otorhinolaryngology of University Hospital Královské Vinohrady and 3rd Medical Faculty, Charles University in Prague. Method Patients with sub-chronic or chronic tinnitus were enrolled in double-blind trial and randomized to receive 120 mg EGb 761 (R) or 600 mg pentoxifylline, each twice a day and in double-dummy fashion over a 12-week period. Main outcome measure changes in 11-Point Box Scales for tinnitus loudness and annoyance, the abridged Tinnitus Questionnaire (Mini-TQ), the Hospital Anxiety and Depression Scale (HADS), and the Sheehan Disability Scale (SDS). Results Full analysis set for efficacy analysis comprised 197 patients (EGb 761 (R) , 99; pentoxifylline 98). For both treatment groups, significant improvements were observed in the Mini-TQ, the 11-Point Box Scales for tinnitus loudness and annoyance, the HADS anxiety score and the SDS. There was no relevant difference with regard to tinnitus-related outcomes between the two treatment groups. 20 adverse events were documented in EGb 761 (R) group and 36 adverse events were reported for pentoxifylline group. No serious adverse event was reported during the study. Conclusion EGb 761 (R) and pentoxifylline were similarly effective in reducing the loudness and annoyance of tinnitus as well as overall suffering of the patients. The incidence of adverse events was lower in the EGb 761 (R) group.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30206 - Otorhinolaryngology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Clinical Pharmacy

  • ISSN

    2210-7703

  • e-ISSN

    2210-7711

  • Volume of the periodical

    40

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    1335-1341

  • UT code for WoS article

    000448698900050

  • EID of the result in the Scopus database

    2-s2.0-85047959755