Burden of sudden cardiac death in persons aged 1-40 years in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43923396" target="_blank" >RIV/00064173:_____/22:43923396 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/22:10157807 RIV/00216208:11130/22:10443090 RIV/00064203:_____/22:10443090 RIV/00216208:11120/22:43923396 and 3 more

Result on the web

<a href="https://doi.org/10.21101/cejph.a6793" target="_blank" >https://doi.org/10.21101/cejph.a6793</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a6793" target="_blank" >10.21101/cejph.a6793</a>

Result language

angličtina

Original language name

Burden of sudden cardiac death in persons aged 1-40 years in the Czech Republic

Original language description

OBJECTIVES: The aim of the study was to ascertain the incidence, circumstances and causes of sudden cardiac death in persons aged 1-40 years in the Czech Republic. METHODS: De-identified autopsy reports of all individuals who died suddenly between the ages of 1-40 years during the period 2014-2019 inclusive in a selected area of the Czech Republic were analysed retrospectively. Persons with substantial cardiovascular pathology defined by histopathological criteria and those with a negative autopsy were included in the study. The latter were designated as sudden arrhythmic death syndrome. RESULTS: In total, 245 sudden cardiac death cases were identified resulting in an incidence rate of 2.4/100,000 person-years. Among the deceased, we found an enormous gender gap with men representing 81% of cases. More than 80% of deaths occurred during everyday activities or sleep, whereas only 7% were sports-related. The most common cause of death was coronary artery disease detected in 38%, which was followed by cardiomyopathies in 15%, sudden arrhythmic death syndrome in 12%, left ventricular hypertrophy in 10%, and congenital heart defects in 7%. CONCLUSIONS: Coronary artery disease is the predominant cause of sudden cardiac death in the young population of the Czech Republic. Hence, effective preventive measures targeted at the reduction of risk factors associated with early coronary artery disease should be reinforced. The second most prevalent cause in our population are potentially heritable heart conditions such as cardiomyopathies and sudden arrhythmic death syndrome. This fact has already prompted the introduction of molecular autopsy and cardiogenetic care for relatives in the Czech Republic.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV18-02-00237" target="_blank" >NV18-02-00237: Detection of sudden cardiac death causes in people aged 0-35 years using molecular genetic methods – a pilot study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

1803-1048

Volume of the periodical

30

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

58-64

UT code for WoS article

000792374000010

EID of the result in the Scopus database

2-s2.0-85128251657