Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and RAGE promising candidates?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43923491" target="_blank" >RIV/00064173:_____/22:43923491 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10443185 RIV/00216208:11120/22:43923491 RIV/00064211:_____/22:W0000005 RIV/00064190:_____/22:N0000033 RIV/00216208:11210/22:10443185

Result on the web

<a href="https://doi.org/10.5507/bp.2022.014" target="_blank" >https://doi.org/10.5507/bp.2022.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2022.014" target="_blank" >10.5507/bp.2022.014</a>

Result language

angličtina

Original language name

Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and RAGE promising candidates?

Original language description

Aims. Inflammatory bowel diseases and colorectal cancer are serious intestinal disorders with continuously increasing incidence. Many aspects of etiopathogenesis still remain unclear. There is an urgent need to improve early diagnostics and markers indicating the progression of the disease. The aim of our study was to analyze the expression of matrix metalloproteinase-19 (MMP-19), and the receptor for advanced glycation end-products (RAGE) in different cell sub-populations in inflammatory bowel diseases (IBD) and colorectal cancer (CRC) compared to the tissue in the vicinity of pathological processes. Methods. Expression of both markers in epithelium, macrophages and vessels were evaluated in IBD and CRC groups. They were detected using immunohistochemistry in paraffin sections. Results. There were significant differences between the expression of MMP-19 on macrophages and vessels among healthy and cancer tissues. In both, macrophages and vessels were significantly lower levels in cancer tissues. The ex-pression of MMP-19 on vessels was also significantly different between peritumoral and cancer tissues (higher levels in peritumoral tissue). RAGE expression in macrophages was significantly different between healthy and cancer tissues and between peritumoral and cancer tissues. There was significantly lower expression in cancer tissues than in healthy and peritumoral tissues. Expression of RAGE in vessels was significantly different just in the comparison of healthy and peritumoral tissues (higher levels in healthy tissues). Conclusion. Both markers seem to be promising potential auxiliary markers in IBD and CRC diagnostics. They can also improve evaluation of disease progression.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

166

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

380-385

UT code for WoS article

000779421900001

EID of the result in the Scopus database

2-s2.0-85143707449