Agrimonia eupatoria L. Aqueous Extract Improves Skin Wound Healing: An In Vitro Study in Fibroblasts and Keratinocytes and In Vivo Study in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43923523" target="_blank" >RIV/00064173:_____/22:43923523 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10443422 RIV/00216208:11120/22:43923523

Result on the web

<a href="https://doi.org/10.21873/invivo.12822" target="_blank" >https://doi.org/10.21873/invivo.12822</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/invivo.12822" target="_blank" >10.21873/invivo.12822</a>

Result language

angličtina

Original language name

Agrimonia eupatoria L. Aqueous Extract Improves Skin Wound Healing: An In Vitro Study in Fibroblasts and Keratinocytes and In Vivo Study in Rats

Original language description

BACKGROUND/AIM: We have previously shown that the water extract of Agrimonia eupatoria L. (AE) is a valuable source of polyphenols with excellent antioxidant properties and has clinical potential for the prevention and/or adjuvant therapy of cardiovascular complications associated with diabetes. Inspired by our previously published data, in the present study we examined whether AE improves skin wound healing in a series of in vitro and in vivo experiments. MATERIALS AND METHODS: In detail, we investigated the ability of the AE extract to induce fibroblast to myofibroblast conversion, extracellular matrix (ECM) deposition, and keratinocyte proliferation/differentiation, in vitro. In parallel, in an animal model, we measured wound tensile strength (TS) and assessed the progression of open wounds using basic histology and immunofluorescence. RESULTS: The AE extract induced the myofibroblast-like phenotype and enhanced ECM deposition, both in vitro and in vivo. Furthermore, the wound TS of skin incisions and the contraction rates of open excisions were significantly increased in the AE-treated group. CONCLUSION: The present data show that AE water extract significantly improves the healing of open and sutured skin wounds. Therefore, our data warrant further testing in animal models that are physiologically and evolutionarily closer to humans.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Center for Tumor Ecology - Research of the cancer microenvironment supporting cancer growth and spread</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

In Vivo

ISSN

0258-851X

e-ISSN

1791-7549

Volume of the periodical

36

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

9

Pages from-to

1236-1244

UT code for WoS article

000793236900003

EID of the result in the Scopus database

2-s2.0-85128939205