PAR2: The Cornerstone of Pancreatic Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F22%3A43924435" target="_blank" >RIV/00064173:_____/22:43924435 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/22:43924435 RIV/00064190:_____/22:N0000013
Result on the web
<a href="https://doi.org/10.33549/physiolres.934931" target="_blank" >https://doi.org/10.33549/physiolres.934931</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934931" target="_blank" >10.33549/physiolres.934931</a>
Alternative languages
Result language
angličtina
Original language name
PAR2: The Cornerstone of Pancreatic Diseases
Original language description
It has been 30 years since the first member of the protease -activated receptor (PAR) family was discovered. This was followed by the discovery of three other receptors, including PAR2. PAR2 is a G protein-coupled receptor activated by trypsin site-specific proteolysis. The process starts with serine proteases acting between arginine and serine, creating an N-terminus that functions as a tethered ligand that binds, after a conformational change, to the second extracellular loop of the receptor, leading to activation of G-proteins. The physiological and pathological functions of this ubiquitous receptor are still elusive. This review focuses on PAR2 activation and its distribution under physiological and pathological conditions, with a particular focus on the pancreas, a significant producer of trypsin, which is the prototype activator of the receptor. The role in acute or chronic pancreatitis, pancreatic cancer, and diabetes mellitus will be highlighted.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
71
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
14
Pages from-to
583-596
UT code for WoS article
000890049600001
EID of the result in the Scopus database
2-s2.0-85149879097