A randomized comparison of His bundle pacing versus right ventricular pacing: Effect on left ventricular function and biomarkers of collagen metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43925254" target="_blank" >RIV/00064173:_____/23:43925254 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43925254

Result on the web

<a href="https://doi.org/10.33963/KP.a2023.0065" target="_blank" >https://doi.org/10.33963/KP.a2023.0065</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33963/KP.a2023.0065" target="_blank" >10.33963/KP.a2023.0065</a>

Result language

angličtina

Original language name

A randomized comparison of His bundle pacing versus right ventricular pacing: Effect on left ventricular function and biomarkers of collagen metabolism

Original language description

Background: Right ventricular pacing (RVP) can result in pacing-induced cardiomyopathy (PICM). It is unknown whether specific biomarkers reflect differences between His bundle pacing (HBP) and RVP and predict a decrease in left ventricular function during RVP. Aims: We aimed to compare the effect of HBP and RVP on the left ventricular ejection fraction (LVEF) and to study how they affect serum markers of collagen metabolism.Methods: Ninety-two high-risk PICM patients were randomized to HBP or RVP groups. Their clinical characteristics, echocardiography, and serum levels of transforming growth factor β1 (TGF-β1), matrix metalloproteinase 9 (MMP-9), suppression of tumorigenicity 2 interleukin (ST2-IL), tissue inhibitor of metalloproteinase 1 (TIMP-1), and galectin 3 (Gal-3) were studied before pacemaker implantation and six months later. Results: Fifty-three patients were randomized to the HBP group and 39 patients to the RVP group. HBP failed in 10 patients, who crossed over to the RVP group. Patients with RVP had significantly lower LVEF compared to HBP patients after six months of pacing (−5% and −4% in as-treated and intention-to-treat analysis, respectively). Levels of TGF-β1 after 6 months were lower in HBP than RVP patients (mean difference −6 ng/ml; P = 0.009) and preimplant Gal-3 and ST2-IL levels were higher in RVP patients, with a decline in LVEF ≥5% compared to those with a decline of <5% (mean difference 3 ng/ml and 8 ng/ml; P = 0.02 for both groups).Conclusion: In high-risk PICM patients, HBP was superior to RVP in providing more physiological ventricular function, as reflected by higher LVEF and lower levels of TGF-β1. In RVP patients, LVEF declined more in those with higher baseline Gal-3 and ST2-IL levels than in those with lower levels.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kardiologia Polska

ISSN

0022-9032

e-ISSN

1897-4279

Volume of the periodical

81

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

472-481

UT code for WoS article

001007976300001

EID of the result in the Scopus database

2-s2.0-85160964918