Employing Adalimumab in Treatment of Moderate-to-Severe Hidradenitis Suppurativa: Real-Life Multicenter Data from the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43925352" target="_blank" >RIV/00064173:_____/23:43925352 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10458727 RIV/00216208:11120/23:43925352 RIV/00064165:_____/23:10458727

Result on the web

<a href="https://doi.org/10.1155/2023/3640285" target="_blank" >https://doi.org/10.1155/2023/3640285</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2023/3640285" target="_blank" >10.1155/2023/3640285</a>

Result language

angličtina

Original language name

Employing Adalimumab in Treatment of Moderate-to-Severe Hidradenitis Suppurativa: Real-Life Multicenter Data from the Czech Republic

Original language description

Adalimumab is the only approved biologic treatment for moderate-to-severe hidradenitis suppurativa, nonetheless, long-term data from real-life setting are still limited. The objective of this observational multicenter study was to evaluate the effectiveness, safety, and drug survival of adalimumab in patients with hidradenitis suppurativa included in the BIOREP registry. A total of 299 patients who initiated adalimumab therapy for hidradenitis suppurativa from 2011 to November 2021 were included. The Dermatology-Life-Quality-Index (DLQI), pain scale, the number of abscesses, inflammatory nodules and draining tunnels, and International Hidradenitis Suppurativa Severity Score System (IHS4) were recorded in the 0(th), 3(rd), and 6(th) months; then every 6 months during the ongoing adalimumab treatment. Studied patients underwent treatment for up to 48 months, with the average duration of treatment lasting 2.3 years. The mean age of the patients was 44.9 years, 79% were smokers or ex-smokers, 54.8% were obese, and 26.4% were overweight, the mean BMI was 30.8. The mean time from diagnosis to initiation adalimumab therapy was 9.1 years. The number of patients with severe IHS4 dropped from the initial 249 (83.3%) to 65 (30.1%) after 12 months and this trend was maintained up to the 48(th) month. A decreasing number of inflammatory lesions were rapid and sustained and correlated to the improvement of patients&apos; quality of life, the mean DLQI score dropped from 17.6 to 8.5 after 3 months and to 5, 7 after 48 months. No unexpected risk signals were observed. Our long-term study demonstrates the effectiveness and safety of adalimumab in a real-life setting.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30216 - Dermatology and venereal diseases

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dermatologic Therapy

ISSN

1396-0296

e-ISSN

1529-8019

Volume of the periodical

2023

Issue of the periodical within the volume

March

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

3640285

UT code for WoS article

000956570900001

EID of the result in the Scopus database

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