Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F23%3A43926066" target="_blank" >RIV/00064173:_____/23:43926066 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00133339 RIV/00216208:11130/23:10469231 RIV/00064203:_____/23:10469231

Result on the web

<a href="https://doi.org/10.1002/jhbp.1359" target="_blank" >https://doi.org/10.1002/jhbp.1359</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jhbp.1359" target="_blank" >10.1002/jhbp.1359</a>

Result language

angličtina

Original language name

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Original language description

BACKGROUND: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]). METHODS: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC. RESULTS: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p &lt; .001). CONCLUSIONS: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Hepato-Biliary-Pancreatic Sciences

ISSN

1868-6974

e-ISSN

1868-6982

Volume of the periodical

30

Issue of the periodical within the volume

12

Country of publishing house

JP - JAPAN

Number of pages

10

Pages from-to

1324-1333

UT code for WoS article

001073545100001

EID of the result in the Scopus database

2-s2.0-85172284704