Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926928" target="_blank" >RIV/00064173:_____/24:43926928 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43926928 RIV/00216208:11130/24:10479549

Result on the web

<a href="https://doi.org/10.3390/diagnostics14080810" target="_blank" >https://doi.org/10.3390/diagnostics14080810</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/diagnostics14080810" target="_blank" >10.3390/diagnostics14080810</a>

Result language

angličtina

Original language name

Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences?

Original language description

In this study, we reviewed CT/MRI scans and studied the rates of radiation-related fractures in subjects treated for cervical cancer (CC, 63 subjects) by radical radiotherapy (RT) and in subjects treated for endometrial cancer (EC, 64 subjects) by radical surgery and RT. The differences between bone density measured in L1 on pretreatment CT, age and body mass index (BMI) were evaluated. Despite significant differences in RT total dose, age, BMI, etc., between both groups, the rate of radiation-related fractures was similar: 28.6% of CC versus 26.6% of EC subjects. CC subjects with fractures were significantly older (62.4 +- 10.1 vs. 49.0 +- 12.4 years; p &lt; 0.001), and their bone densities were significantly lower (106.3 +- 40.0 vs. 168.2 +- 49.5 HU; p &lt; 0.001); no difference in BMI was found. EC subjects with fractures were without significant difference in age but had significantly lower bone densities (103.8 +- 29.0 vs. 133.8 +- 42.3 HU; p = 0.009) and BMIs (26.1 +- 4.9 vs. 31.8 +- 6.9 kg/m2; p = 0.003). Bone density strongly correlated with age (r = MINUS SIGN 0.755) only in CC subjects. Subjects with fractures from both groups had similarly low bone densities (106.3 +- 40.0 vs. 103.8 +- 29.0 HU; p = 0.829); however, no correlation between bone density and BMI was found. The rate of radiation-related fractures in both groups was clearly associated only with low pretreatment bone density, reflecting osteoporosis

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diagnostics

ISSN

2075-4418

e-ISSN

2075-4418

Volume of the periodical

14

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

810

UT code for WoS article

001211441700001

EID of the result in the Scopus database

2-s2.0-85191406031