Expression of selected miRNAs in undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas: comparison with poorly differentiated pancreatic ductal adenocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43926977" target="_blank" >RIV/00064173:_____/24:43926977 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43926977 RIV/00064165:_____/24:10479920
Result on the web
<a href="https://doi.org/10.3390/biomedicines12050962" target="_blank" >https://doi.org/10.3390/biomedicines12050962</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines12050962" target="_blank" >10.3390/biomedicines12050962</a>
Alternative languages
Result language
angličtina
Original language name
Expression of selected miRNAs in undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas: comparison with poorly differentiated pancreatic ductal adenocarcinoma
Original language description
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal adenocarcinoma is particularly challenging, with limited prospects for cure. As with many other malignant neoplasms, the exploration of microRNAs (miRNAs, miRs) in regulating the biological characteristics of pancreatic cancer is undergoing extensive investigation to enhance tumor diagnostics and unveil the therapeutic possibilities. Herein, we evaluated the expression of miR-21, -96, -148a, -155, -196a, -210, and -217 in UCOGCs and poorly differentiated (grade 3, G3) PDACs. The expression of miR-21, miR-155, and miR-210 in both UCOGCs and G3 PDACs was significantly upregulated compared to the levels in normal tissue, while the levels of miR-148a and miR-217 were downregulated. We did not find any significant differences between cancerous and normal tissues for the expression of miR-96 and miR-196a in G3 PDACs, whereas miR-196a was slightly, but significantly, downregulated in UCOGCs. On the other hand, we have not observed significant differences in the expression of the majority of miRNAs between UCOGC and G3 PDAC, with the exception of miR-155. UCOGC samples demonstrated lower mean levels of miR-155 in comparison with those in G3 PDACs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
12
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
962
UT code for WoS article
001232414600001
EID of the result in the Scopus database
2-s2.0-85194102336