An extensive immunohistochemical analysis of 290 ovarian adult granulosa cell tumors with 29 markers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43927256" target="_blank" >RIV/00064173:_____/24:43927256 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00136362 RIV/00209805:_____/24:00079902 RIV/00216208:11110/24:10481490 RIV/00216208:11120/24:43927256 and 7 more

Result on the web

<a href="https://doi.org/10.1007/s00428-024-03854-0" target="_blank" >https://doi.org/10.1007/s00428-024-03854-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00428-024-03854-0" target="_blank" >10.1007/s00428-024-03854-0</a>

Result language

angličtina

Original language name

An extensive immunohistochemical analysis of 290 ovarian adult granulosa cell tumors with 29 markers

Original language description

The current knowledge about the immunohistochemical features of adult granulosa cell tumor (AGCT) is mostly limited to the &quot;traditional&quot; immunohistochemical markers of sex cord differentiation, such as inhibin, calretinin, FOXL2, SF1, and CD99. Knowledge about the immunohistochemical markers possibly used for predictive purpose is limited. In our study, we focused on the immunohistochemical examination of 290 cases of AGCT classified based on strict diagnostic criteria, including molecular testing. The antibodies used included 12 of the &quot;diagnostic&quot; antibodies already examined in previous studies, 10 antibodies whose expression has not yet been examined in AGCT, and 7 antibodies with possible predictive significance, including the expression of HER2, PD-L1, CTLA4, and 4 mismatch repair (MMR) proteins. The results of our study showed expression of FOXL2, SF1, CD99, inhibin A, calretinin, ER, PR, AR, CKAE1/3, and CAIX in 98%, 100%, 90%, 78%, 45%, 41%, 94%, 82%, 26%, and 9% of AGCT, respectively. GATA3, SATB2, napsin A, MUC4, TTF1, and CD44 were all negative. PTEN showed a loss of expression in 71% of cases and DPC4 in 4% of cases. The aberrant staining pattern (overexpression) of p53 was found in 1% (3/268) of cases, 2 primary tumors, and 1 recurrent case. Concerning the predictive markers, the results of our study showed that AGCT is microsatellite stable, do not express PD-L1, and are HER2 negative. The CTLA4 expression was found in almost 70% of AGCT tumor cells.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30109 - Pathology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Virchows Archiv

ISSN

0945-6317

e-ISSN

1432-2307

Volume of the periodical

485

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

427-437

UT code for WoS article

001251527400001

EID of the result in the Scopus database

2-s2.0-85196549137