Distribution of mechanical properties of native human ligamentum flavum depending on histopathological changes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43927529" target="_blank" >RIV/00064173:_____/24:43927529 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927529 RIV/68407700:21220/24:00376809
Result on the web
<a href="https://doi.org/10.1088/2057-1976/ad78e2" target="_blank" >https://doi.org/10.1088/2057-1976/ad78e2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/2057-1976/ad78e2" target="_blank" >10.1088/2057-1976/ad78e2</a>

Result language
angličtina
Original language name
Distribution of mechanical properties of native human ligamentum flavum depending on histopathological changes
Original language description
This study aimed to characterize the mechanical properties of native human ligamentum flavum (LF) and correlate them with histopathological changes. Mechanical property gradients across the cranial, medial, and caudal regions of LF were mapped and compared with histological sections. We also compared lumbar spinal stenosis (LSS) samples with disc herniation (DH) samples as reference material to identify differences in mechanical properties and histopathological features. Our results revealed significant heterogeneity in LF mechanical properties, with local variations correlating with specific histopathological changes such as chondroid metaplasia and loss of elastic fibers. These findings underscore the importance of considering LF heterogeneity in mechanical characterization and provide insights into its behavior under pathological conditions.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30211 - Orthopaedics

Project
<a href="/en/project/NU21-06-00356" target="_blank" >NU21-06-00356: Changes in vascular density, physical and histopathobiochemical properties of ligamentum flavum in lumbar spine based on spinal segment levels and anatomical localization and presence of lumbar spinal stenosis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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