Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928409" target="_blank" >RIV/00064173:_____/25:43928409 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928409
Result on the web
<a href="https://doi.org/10.1080/14737159.2025.2485211" target="_blank" >https://doi.org/10.1080/14737159.2025.2485211</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14737159.2025.2485211" target="_blank" >10.1080/14737159.2025.2485211</a>
Alternative languages
Result language
angličtina
Original language name
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma
Original language description
INTRODUCTION: Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) is a rare but serious condition requiring accurate diagnostics. Cerebrospinal fluid (CSF) analysis plays a crucial role, particularly in cases where biopsy is not feasible, and imaging is inconclusive. AREAS COVERED: This review examines both traditional and emerging methods for CSF analysis in diagnosing CNS involvement in DLBCL. Conventional approaches such as cytomorphology, flow cytometry, and biochemical markers have limitations, particularly in low-cellularity samples. Novel molecular techniques, including circulating tumor DNA (ctDNA) analysis and microRNAs (miRNAs), are gaining prominence for their ability to detect gene mutations at diagnosis and monitor minimal residual disease during follow-up. The sensitivity and specificity of genetic mutations, particularly MYD88 L265P, in combination with interleukin-10 (IL-10) levels, are discussed. The literature search methodology involved reviewing relevant studies and clinical data. EXPERT OPINION: Advancements in CSF biomarker analysis are improving the diagnosis of CNS lymphoma, aiding early detection and personalized treatment approaches. However, further research and broader clinical validation are necessary for their routine implementation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Review of Molecular Diagnostics
ISSN
1473-7159
e-ISSN
1744-8352
Volume of the periodical
25
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
209-215
UT code for WoS article
001488701800001
EID of the result in the Scopus database
2-s2.0-105005541495