The impact of pre-existing aortic stenosis and mitral regurgitation on patients with acute myocardial infarction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928469" target="_blank" >RIV/00064173:_____/25:43928469 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/25:00085641 RIV/00216224:14110/25:00141283 RIV/00216208:11120/25:43928469 RIV/00216208:11140/25:10498161 and 5 more
Result on the web
<a href="https://doi.org/10.1038/s41598-025-01313-7" target="_blank" >https://doi.org/10.1038/s41598-025-01313-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-01313-7" target="_blank" >10.1038/s41598-025-01313-7</a>
Alternative languages
Result language
angličtina
Original language name
The impact of pre-existing aortic stenosis and mitral regurgitation on patients with acute myocardial infarction
Original language description
The prevalence of left-sided valvular heart disease (VHD) increases with age, but data on the impact of pre-existing VHD in patients with acute myocardial infarction (AMI) are limited. We aimed to define the clinical characteristics and outcomes of AMI patients with pre-existing left VHD. The analysis is based on data from three merged national registries. The dataset included 47,436 patients admitted with AMI over a 5year period at all Cath Labs nationwide. Pre-existing VHD was diagnosed in 1,445 patients (3.0%), moderate-to-severe mitral regurgitation (MR) in 510 patients (35.3%), and moderate-to-severe aortic stenosis (AS) in 869 patients (60.1%). Patients with VHD had worse baseline characteristics, pre-existing coronary artery disease, more complicated in-hospital course with higher Killip class, lower left ventricular ejection fraction, and more comorbidities. Angiographically more frequent left main stenosis, TIMI flow 3 before PCI, less frequent stent implantation. Patients with pre-existing VHD had significantly higher 7-day (10.1% vs. 4.5%, p < 0.001), 30-day (16.0% vs. 7.0%, p < 0.001) and 1-year mortality (28.7 vs. 12.7%, p < 0.001) compared to patients without. Conclusions. Patients with pre-existing VHD and AMI are characterized by complicated in-hospital course with higher Killip class, lower ejection fraction, angiographically less severe stenosis, TIMI flow 3 prior to PCI, and less frequent stent implantation. This is a high-risk group with higher short - and long-term mortality and earlier intervention should be considered.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
17449
UT code for WoS article
001493896700002
EID of the result in the Scopus database
2-s2.0-105005537929