Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928647" target="_blank" >RIV/00064173:_____/25:43928647 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928647
Result on the web
<a href="https://doi.org/10.1080/1354750X.2025.2536009" target="_blank" >https://doi.org/10.1080/1354750X.2025.2536009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/1354750X.2025.2536009" target="_blank" >10.1080/1354750X.2025.2536009</a>
Alternative languages
Result language
angličtina
Original language name
Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy
Original language description
INTRODUCTION: The mechanism of cell death during pulsed-field (PFA) ablation seems substantially different from mechanisms using thermal energy sources (e.g., radiofrequency energy, RFA). In human in vivo studies, apoptosis is often described as the leading cause of PFA-induced cell death. This study aimed to specify the cause by comparing markers of cardiac necrosis and apoptosis during ablation using PFA and RFA energy. METHODS AND RESULTS: Patients with AF indicated for pulmonary vein isolation (PVI) were enrolled and randomly assigned to undergo PVI using RFA (CARTO Smart Touch, Biosense Webster) or PFA (Farapulse, Boston-Scientific) energy. Markers of myocardial necrosis (troponin I) and apoptosis (soluble cleaved caspase-3, Fas ligand) were measured before and one day after the procedure. RESULTS: Sixty-five patients were enrolled in the PFA (n = 33) and RFA (n = 32) groups. Both groups had similar baseline characteristics (age 60.5 +- 12.7 vs. 64.0 +- 10.7; paroxysmal AF 60.6% vs. 62.5% of patients). The maximum troponin concentration on 1d + was substantially higher in the PFA group (median and interquartile rages) 10,102 ng/L; 8,272-14,207 vs. 1,006 ng/L; 603-1,433). No increase in Fas or caspase-3 was present after PFA, and no differences in the concentration of these apoptotic markers were present between PFA and RFA patients 1d after the procedure. CONCLUSION: In the acute clinical in vivo setting, apoptosis does not seem to be the leading cause of cardiomyocyte death after pulsed-field ablation for AF.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NU21-02-00388" target="_blank" >NU21-02-00388: Catheter Ablation vs. Risk Factor Modification</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomarkers
ISSN
1354-750X
e-ISSN
1366-5804
Volume of the periodical
30
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
327-331
UT code for WoS article
001541428400001
EID of the result in the Scopus database
2-s2.0-105012426500