Adherence to suppression therapy guidelines after thyroid cancer surgery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43928867" target="_blank" >RIV/00064173:_____/25:43928867 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928867 RIV/00216208:11130/25:10503594
Result on the web
<a href="https://doi.org/10.1007/s44411-025-00377-1" target="_blank" >https://doi.org/10.1007/s44411-025-00377-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s44411-025-00377-1" target="_blank" >10.1007/s44411-025-00377-1</a>
Alternative languages
Result language
angličtina
Original language name
Adherence to suppression therapy guidelines after thyroid cancer surgery
Original language description
Objective: Thyroid-stimulating hormone (TSH) suppression therapy with levothyroxine is essential for patients with differentiated thyroid cancer (DTC) after surgery. While it reduces recurrence risk in high-risk patients, its intensity should be tailored according to risk stratification. This study aimed to evaluate physicians' adherence to recommendations on TSH suppression therapy in patients with DTC after surgery and/or radioiodine therapy. Design: This prospective study included patients managed at two specialized centres following total thyroidectomy for DTC. Methods: Patients on a stable levothyroxine dose for at least three months were enrolled. Data collected at the last follow-up included serum TSH, free thyroxine (FT4), free triiodothyronine (FT3), thyroglobulin, and anti-thyroglobulin antibody levels. TSH values were categorized as within target range, below target (over-suppressed), or above target (under-suppressed) according to American Thyroid Association guidelines and recurrence risk (low, intermediate, high). Results: Of 365 patients (female/male ratio: 306/59; mean age: 54.7 years for females, 56.3 years for males), only 136 (37.3%) achieved target TSH levels. TSH was under-suppressed in 86 patients (23.6%) and over-suppressed in 129 patients (35.3%). Over-suppression was most prevalent (62%) in the low-risk group. Conclusions: Adherence to guideline-recommended TSH suppression therapy in DTC remains suboptimal, with frequent over-suppression, particularly in low-risk patients. These findings highlight the need for individualized suppression strategies balancing recurrence prevention and the avoidance of iatrogenic complications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislava Medical Journal
ISSN
0006-9248
e-ISSN
1336-0345
Volume of the periodical
126
Issue of the periodical within the volume
12
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
3651-3657
UT code for WoS article
001590701900001
EID of the result in the Scopus database
2-s2.0-105018343590