The rise of Candidozyma auris in Czechia: three clades, prosthetic joint infection and fluconazole resistance development, 2022 to 2024
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43929045" target="_blank" >RIV/00064173:_____/25:43929045 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/25:00001607 RIV/00216208:11110/25:10505310 RIV/00216208:11130/25:10505310 RIV/00064211:_____/25:W0000081 and 2 more
Result on the web
<a href="https://doi.org/10.2807/1560-7917.ES.2025.30.45.2500285" target="_blank" >https://doi.org/10.2807/1560-7917.ES.2025.30.45.2500285</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2807/1560-7917.ES.2025.30.45.2500285" target="_blank" >10.2807/1560-7917.ES.2025.30.45.2500285</a>
Alternative languages
Result language
angličtina
Original language name
The rise of Candidozyma auris in Czechia: three clades, prosthetic joint infection and fluconazole resistance development, 2022 to 2024
Original language description
BACKGROUNDCandidozyma auris has emerged globally as a major threat to public health due to its outbreak causing capacity and antifungal resistance. Outbreaks have proven difficult to control despite enhanced infection prevention measures. Thus, national surveillance is warranted.AIMWe aim to characterise the epidemiology of C. auris cases in Czechia between 2022 and 2024 to investigate whether autochthonous spread is occurring and asses antifungal resistance.METHODSHigh-resolution genotyping was performed to assess genetic relatedness between isolates. Microbroth dilution was performed on all isolates and underlying mechanisms resistance were inspected with whole genome sequencing.RESULTSEight cases from seven different hospitals were reported, mainly collected from non-sterile sites, in addition to the first documented prosthetic joint infection by C. auris. Only two patients reported travel history. Three clades were found, with the first report of Clade IV in Europe. For one patient, initial isolates were pan-susceptible but after short exposure to fluconazole became resistant with a novel mechanism.CONCLUSIONC. auris reported in Czechia in patients without travel history suggests autochthonous spread. Three clades were present, often with unknown route of introduction. Development of fluconazole resistance upon brief exposure highlights the ability of C. auris to rapidly evolve.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Eurosurveillance
ISSN
1025-496X
e-ISSN
1560-7917
Volume of the periodical
30
Issue of the periodical within the volume
45
Country of publishing house
SE - SWEDEN
Number of pages
11
Pages from-to
2500285
UT code for WoS article
001651220200001
EID of the result in the Scopus database
2-s2.0-105021712533