Low GATA3 predicts worse survival in penile cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F25%3A43929075" target="_blank" >RIV/00064173:_____/25:43929075 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10505499 RIV/00216208:11120/25:43929075 RIV/00064190:_____/25:10001424 RIV/00064165:_____/25:10505499
Result on the web
<a href="https://doi.org/10.1038/s41598-025-24166-6" target="_blank" >https://doi.org/10.1038/s41598-025-24166-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-24166-6" target="_blank" >10.1038/s41598-025-24166-6</a>
Alternative languages
Result language
angličtina
Original language name
Low GATA3 predicts worse survival in penile cancer
Original language description
Penile squamous cell carcinoma (pSCC) is a rare genitourinary tumor associated with notable psychosexual distress and poor prognosis. Traditional prognostic factors for pSCC include TNM stage and histological grade, with lymph node metastases being a critical indicator of poor prognosis. This study aimed to evaluate the prognostic impact of the following immunohistochemistry markers routinely used in histopathology practice: GATA3, IMP3, HIF-1-α, CK7, CA-IX, HER2, and TTF-1. A retrospective cohort of 145 patients with pSCC was analyzed using tissue microarray and immunohistochemical techniques. Overall survival (OS) was correlated statistically with detected marker expression. Key findings include that low GATA3 expression is associated with significantly worse OS in univariate Cox regression truncated at 3 years of follow-up. Low GATA3 retained prognostic impact when adjusted for major clinicopathological variables: Age, pT and pN stage, grade, lymphatic, venous, and perineural invasion, lymphocytic infiltrate, and expression of p16, p53, and PD-L1. Low GATA3 expression was associated with shorter cancer-specific survival (CSS) at 10 years follow-up. IMP3, CK7, and CA-IX showed statistically insignificant trends towards poorer prognosis. CK7 and CA-IX were more frequently expressed in high grade pSCC and in p16/HPV-positive tumors. IMP3 and CA-IX were associated with regional lymph node metastases. All cases were negative in TTF-1 and HER2. This study suggests GATA3 as a potential prognostic marker in pSCC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NU21J-03-00019" target="_blank" >NU21J-03-00019: The prognostic predictive markers in penile carcinoma: a molecular and morphological study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
40321
UT code for WoS article
001617753400016
EID of the result in the Scopus database
2-s2.0-105022127164