A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon (R)) as a structure modifying therapy in osteoarthritis of the hip and knee

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F00%3A%230000956" target="_blank" >RIV/00064190:_____/00:#0000956 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1053/joca.1999.0307" target="_blank" >http://dx.doi.org/10.1053/joca.1999.0307</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/joca.1999.0307" target="_blank" >10.1053/joca.1999.0307</a>

Result language

angličtina

Original language name

A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon (R)) as a structure modifying therapy in osteoarthritis of the hip and knee

Original language description

To determine the structure (disease) modifying effect of a glycosaminoglycan polypeptide association complex (GP-C; Rumalon(R)) in patients with knee and hip osteoarthritis (OA). Methods: Double-blind, randomized, placebo-controlled five-year study. Primary assessment criterion was change in radiographic joint space width between baseline and follow-up at 5 years. Secondary outcome criteria included Lequesne algofunctional index (LAI), pain on passive motion and consumption of non-steroidal antiinflammatory drugs (NSAIDs). The patients received 10 courses of injections of placebo or GP-C 2 mi intramuscularly in 5 years (two courses each year). Each course included 15 injections administered twice weekly. Results: There were 277 patients with knee OA and 117 patients with hip OA. Control and GP-G treated groups were comparable as to sex, age, duration of disease, body weight, X-ray stage and value of LAI at the baseline. Knee joint space at 5 years decreased 0.37+/-0.08 (mean+/-standard

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

OSTEOARTHRITIS AND CARTILAGE

ISSN

1063-4584

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

335-342

UT code for WoS article

000089316600002

EID of the result in the Scopus database

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