Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP- 43 in Motor Neuron Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F10%3A%230000024" target="_blank" >RIV/00064190:_____/10:#0000024 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/10:#0000145

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP- 43 in Motor Neuron Disease

Original language description

In the present study, using a neuron-specific morphometric approach, we examined the expression of the early endosomal marker Rab5 and lysosomal cathepsins B, D, F, and L as well as PAS-stained structures. This was compared with the expression of ubiquitin, p62 and TDP-43 and its phosphorylated form. The principal finding was the increased expression of the endosomal marker Rab5 and lysosomal cathepsin D, and of PAS-positive structures in motor neurons of MND cases. Furthermore, the area-portion of Rab5immunoreactivity correlated well with the intracellular accumulation of ubiquitin, p62 and (phosphorylated) TDP-43. However, double immunolabelling and immunogold electron microscopy excluded co-localization of phosphorylated TDP-43 with the ELS. Thesedata contrast with observations on neuronal cytopathology in Alzheimer`s or prion diseases where the disease-specific proteins are processed withing endosomes, and suggest a distinct role of the ELS in MND.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NR8491" target="_blank" >NR8491: The relationship between amyotrophic lateral sclerosis and the degree of cognitive impairment, markers of neurodegeneration and brain atrophy. A prospective study.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Neurology

ISSN

0014-4886

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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