Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230000684" target="_blank" >RIV/00064190:_____/14:#0000684 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/14:10283046 RIV/00064190:_____/14:#0000816 RIV/00216208:11110/14:10283046 RIV/00216208:11130/14:10283046
Result on the web
<a href="http://dx.doi.org/10.1016/j.critrevonc.2013.10.001" target="_blank" >http://dx.doi.org/10.1016/j.critrevonc.2013.10.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.critrevonc.2013.10.001" target="_blank" >10.1016/j.critrevonc.2013.10.001</a>

Result language
angličtina
Original language name
Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application
Original language description
Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men characterized by distinct biologic features and clinical behavior. Both genetic predispositions and environmental factors probably play a substantial role in their etiology. TGTCs arise from a malignant transformation of primordial germ cells in a process that starts prenatally, is often associated with a certain degree of gonadal dysgenesis, and involves the acquirement of several specific aberrations, including activation of SCF-CKIT, amplification of 12p with up-regulation of stem cell genes, and subsequent genetic and epigenetic alterations. Their embryonic and germ origin determines the unique sensitivity of TGCTs to platinum-based chemotherapy. Contrary to thevast majority of other malignancies, no molecular prognostic/predictive factors nor targeted therapy is available for patients with these tumors. This review summarizes the principal molecular characteristics of TGCTs that could represen
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT12414" target="_blank" >NT12414: The impact of WT1 gene and other molecular-biologic abnormalities as potential prognostic and predictive factors in testicular germ-cell tumors</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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