Impact of Anti?Tumor Necrosis Factor Alpha Antibodies Administered to Pregnant Women With Inflammatory Bowel Disease on Long-term Outcome of Exposed Children
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F14%3A%230000750" target="_blank" >RIV/00064190:_____/14:#0000750 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/14:10271962 RIV/00216208:11130/14:10271962 RIV/00216208:11140/14:10271962 RIV/00669806:_____/14:10271962 and 4 more
Result on the web
<a href="http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f" target="_blank" >http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/01.MIB.0000440984.86659.4f" target="_blank" >10.1097/01.MIB.0000440984.86659.4f</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Anti?Tumor Necrosis Factor Alpha Antibodies Administered to Pregnant Women With Inflammatory Bowel Disease on Long-term Outcome of Exposed Children
Original language description
Background:Prenatal exposure to anti?tumor necrosis factor alpha (TNF-alpha) antibodies seems to be safe for fetal development. Data on long-term outcome of exposed children are missing. Our aim was to assess long-term postnatal development of children exposed to anti?TNF-alpha during pregnancy. Methods:Consecutive children aged equal to or more than 12 months exposed to anti-TNFs prenatally for maternal inflammatory bowel disease in 3 centers in the Czech Republic were enrolled. Data on psychomotor development, infections, antibiotics, vaccination, and allergy were retrospectively obtained from mothers, treating pediatricians, and children's vaccination cards. Furthermore, standardized laboratory tests on humoral and cellular immunity were performed.Results:Twenty-five children exposed to biologicals were included (median age, 34 mo; range, 14?70 mo). All children had normal growth, and all but 1 had normal psychomotor development. Majority (80%) experienced at least 1 infection (mai
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14300" target="_blank" >NT14300: Aetiology, pathogenesis and clinical course of skin and immunopathological adverse events of biological therapy in inflammatory bowel disease</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inflammatory bowel diseases
ISSN
1078-0998
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
495-501
UT code for WoS article
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EID of the result in the Scopus database
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