Suppressive effect of citalopram on plasma concentrations of thromboxane B-2
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F15%3A%230001076" target="_blank" >RIV/00064190:_____/15:#0001076 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/15:10297941
Result on the web
<a href="http://dx.doi.org/10.3109/00365513.2015.1066848" target="_blank" >http://dx.doi.org/10.3109/00365513.2015.1066848</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00365513.2015.1066848" target="_blank" >10.3109/00365513.2015.1066848</a>
Alternative languages
Result language
angličtina
Original language name
Suppressive effect of citalopram on plasma concentrations of thromboxane B-2
Original language description
Background. Citalopram, a selective serotonin reuptake inhibitor (SSRi), is widely used to treat major depression. Patients treated with SSRIs suffer more frequently from bleeding disorders caused by the antiplatelet effect of SSRIs. Methods. To investigate the potential suppressive effect of citalopram treatment on plasma thromboxane B-2 levels and its possible correlation with actual plasma concentration of citalopram. Plasma concentrations of thromboxane B-2 and citalopram were examined in a cohort of 77 aspirin-treated geriatric patients before and in the third week of citalopram therapy. Results. Citalopram therapy led to a signifi cant decrease of plasma concentrations of thromboxane B-2 compared to its levels before initiation of the therapy. Furthermore, we have shown negative correlation in thromboxane B-2 levels and actual plasma concentration of citalopram. Actual plasma concentrations of citalopram were signifi cantly higher compared to younger adult patients treated with similar dose. Conclusions. In this study we have shown that even short-term citalopram therapy led to a suppression of thromboxane B-2 production in aspirin-treated patients. This suppressive effect correlates with actual plasma concentration of citalopram.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
ISSN
0036-5513
e-ISSN
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Volume of the periodical
75
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
615-620
UT code for WoS article
000361321700012
EID of the result in the Scopus database
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