Cognitive performance in patients with acute phase of bipolar disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000043" target="_blank" >RIV/00064190:_____/18:N0000043 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14735/amcsnn2018320" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018320</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2018320" target="_blank" >10.14735/amcsnn2018320</a>

Result language

angličtina

Original language name

Cognitive performance in patients with acute phase of bipolar disorder

Original language description

Aim: The aim of this study was to evaluate the cognitive performance of bipolar disorder patients in the acute phase of the illness. The interest was in determining if the cognitive performance would vary, depending on the different acute phase and if the clinical characteristics were related to the clinical course and the cognitive performance level. Patients and methods: A total of 53 patients with bipolar disorder, of which 16 were in hypomania, 17 in mania, 20 in depression, and 23 healthy control group subjects were examined by complex neuropsychological assessment tools. Results: Patients with bipolar disorder exhibited cognitive impairment in the area of psychomotor speed, attention, verbal memory and, to a lesser extent, in executive functions and visual memory. Bipolar patients compared to the control group showed statistically significantly worse performance in all cognitive tests except the initiation time (TOL tit) (U = 480; p = 0.142). The healthy control group subjects performed all of the tests within normal standards. Comparison of cognitive performances in the different phases, reflected a statistically significant difference in all cognitive tests except for TOL tit (H = 6.464; p = 0.091), where the four groups did not differ statistically. Cognitive performance in acute phases did not show a statistically significant difference in either of the cognitive tests. After taking into account the clinical characteristics, the closest correlation was recorded between the onset of the illness and verbal memory AVLT 1 (r = -0.452; p < 0.01), AVLT Sum (r = -0.383; p < 0.01), and AVLT 30 (r = -0.370; p < 0.01).Conclusions:In this study, patients in the acute phase of bipolar disorder showed significantly worse performance in all neuropsychological parameters than the healthy control group subjects. Cognitive impairment was recorded in the domain of psychomotor speed, attention, verbal memory and, to a lesser extent, executive functions and visual memory. Patients in hypomania, mania and depression did not differ significantly in cognitive performance. From the clinical characteristics, only the age of onset of the illness showed the most correlations with cognitive variables.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ČESKÁ A SLOVENSKÁ NEUROLOGIE A NEUROCHIRURGIE

ISSN

1210-7859

e-ISSN

1802-4041

Volume of the periodical

81

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

320-329

UT code for WoS article

000433570400013

EID of the result in the Scopus database

2-s2.0-85048056230