Neuropathological post-mortem examination of the brain and the spinal cord in ten key points - What can a neurologist expect from the neuropathologist's confirmation of the clinical diagnosis in neurodegenerative diseases?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000045" target="_blank" >RIV/00064190:_____/18:N0000045 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14735/amcsnn2018109" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2018109" target="_blank" >10.14735/amcsnn2018109</a>

Result language

angličtina

Original language name

Neuropathological post-mortem examination of the brain and the spinal cord in ten key points - What can a neurologist expect from the neuropathologist's confirmation of the clinical diagnosis in neurodegenerative diseases?

Original language description

Standardized brain and spinal cord autopsy is a key feedback mechanism for clinical diagnosis of neurodegenerative diseases. Clinical diagnostic criteria in neurodegenerative disorders reach the "pos sible" and "probable" levels. Neuropathological brain examination is often the only diagnostic modality able to confirm the "defi nite" level of diagnosis in dementia, behavior disorders and movement disorders and thus serves as an invaluable feedback for the clinician; and in clinical studies, it is used to assess therapy-related changes and validate potential diagnostic and prognostic biomarkers. The brain and spinal cord autopsy is performed following a standardized protocol analyzing all diagnostically relevant structures. Precise diagnostic procedures are performed using standard and special histological and histochemical staining; however, only a standardized set of special immunohistochemical investigations can confirm the precise neuropathological diagnosis in neurodegenerative diseases. The purpose of the article is to provide clinical neurologists in 10 points with a brief and practical overview about the usefulness of brain and spinal cord autopsy in neurodegenerative disease and about what the clinician can expect from the neuropathological protocol.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ČESKÁ A SLOVENSKÁ NEUROLOGIE A NEUROCHIRURGIE

ISSN

1210-7859

e-ISSN

1802-4041

Volume of the periodical

81

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

109-114

UT code for WoS article

000429303400020

EID of the result in the Scopus database

2-s2.0-85041724271