Left ventricular hypertrophy in females with hypertension is associated with a poor prognosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F18%3AN0000130" target="_blank" >RIV/00064190:_____/18:N0000130 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.ijcard.2018.01.092" target="_blank" >https://doi.org/10.1016/j.ijcard.2018.01.092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijcard.2018.01.092" target="_blank" >10.1016/j.ijcard.2018.01.092</a>
Alternative languages
Result language
angličtina
Original language name
Left ventricular hypertrophy in females with hypertension is associated with a poor prognosis
Original language description
Background: In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). Methods: 12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospective Campania Salute Network registry were followed over a median of 4.1 years. Subjects were grouped according to the absence or the presence of LVH identified by echocardiography using validated sex-specific cut-off values of LV mass index (N47 g/m2.7 in women and N50 g/m2.7 in men). Main outcome was major cardiovascular events (MACE; combined acute coronary syndromes, stroke, hospitalization for heart failure and incident atrial fibrillation). Results: The cardiovascular risk profile accompanying LVH did not differ between sexes, but presence of obesity and diabetes carried higher probability for LVH in women, and LVH was more prevalent in women than men (43.4 vs. 32.1%, p b 0.001). Among patients without LVH (n = 7764), women had a 35% lower hazard rate (HR) for MACE (n = 179) than men (95% confidence interval [CI] 0.44–0.96, p = 0.031) in Cox regression analysis adjusting for cardiovascular risk factors and antihypertensive treatment during follow up. In contrast, among patients with LVH (n = 4565), women had a similar HR for MACE as men (HR 0.94 [95% CI 0.69–1.30], p = 0.720). Conclusion: This study demonstrates that presence of LVH in hypertension offsets the female sex-protection in cardiovascular risk. Thus among hypertensive subjects with LVH, women and men have comparable cardiovascular risk.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF CARDIOLOGY
ISSN
0167-5273
e-ISSN
1874-1754
Volume of the periodical
258
Issue of the periodical within the volume
05/2018
Country of publishing house
IE - IRELAND
Number of pages
2
Pages from-to
277-278
UT code for WoS article
000427605700059
EID of the result in the Scopus database
2-s2.0-85043469222