Expression and prognostic significance of programmed death-ligand 1 (PD-L1) in Merkel cell carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000033" target="_blank" >RIV/00064190:_____/19:N0000033 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10401972 RIV/00216208:11150/19:10401972

Result on the web

<a href="https://jbuon.com/archive/24-5-2155.pdf" target="_blank" >https://jbuon.com/archive/24-5-2155.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expression and prognostic significance of programmed death-ligand 1 (PD-L1) in Merkel cell carcinoma

Original language description

urpose: To detect the expression of programmed death-ligand 1 (PD-L1) in Merkel cell carcinoma (MCC) and to determine the prognostic influence of the PD-L1 expression. Methods: A total of 13 patients with MCC were retrospectively evaluated (12 patients with primary skin lesion, one patient was diagnosed as unknown primary MCC). All patients underwent surgical resection. PD-L1 was determinated by imunohistochemistry. Immunostaining results were evaluated semiquantitatively. The prognostic influence of the expression of PD-L1 on overall survival (OS) was calculated with the Kaplan-Meier method and log-rank test. Results: PD-L1 positivity was detected in 8 patients (61.5%), in all cases the result was 1+. PD-L1 negativity was shown in the remaining 5 patients. In patients with PD-L1 positivity median OS was 42.1 months (95% CI 9.3-42.1) compared with median OS of 9.4 months (95% CI 2.1-80.9) in the group of patients without PD-L1 positivity (p=0.417). Conclusions: PD-L1 positivity was found in 61.5% of patients with MCC. No prognostic significance of PD-L1 expression for OS was demonstrated.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF BUON

ISSN

1107-0625

e-ISSN

2241-6293

Volume of the periodical

24

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

2155-2160

UT code for WoS article

000501762000057

EID of the result in the Scopus database

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