The prognostic importance of subclinical heart failure in stable coronary heart disease patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000069" target="_blank" >RIV/00064190:_____/19:N0000069 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/20:10395978 RIV/00669806:_____/20:10395978 RIV/00064190:_____/20:N0000114 RIV/00216208:11110/20:10395978
Result on the web
<a href="http://dx.doi.org/10.1080/00015385.2019.1590958" target="_blank" >http://dx.doi.org/10.1080/00015385.2019.1590958</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00015385.2019.1590958" target="_blank" >10.1080/00015385.2019.1590958</a>
Alternative languages
Result language
angličtina
Original language name
The prognostic importance of subclinical heart failure in stable coronary heart disease patients
Original language description
Background: In stable coronary heart disease (CHD) patients we aimed to assess the predictive potential of only mild increase of brain natriuretic peptide (BNP) in subjects free from symptoms or diagnostic criteria of heart failure (HF). Methods: We examined 967 patients, at least 6 months after myocardial infarction or coronary revascularization and divided them into three categories: 'overt HF' (NYHA II-IV, objective signs of HF, chronic treatment with furosemide and/or spironolactone or history of hospitalisation for HF), 'subclinical HF (BNP over 150 ng/mL, but no criterion of overt HF)' and 'no HF' (no above mentioned criterion present). Follow-up was done to assess 5-years all-cause mortality. Results: Overt and subclinical HF (by definition) had 38.8% and 9.6% of patients, respectively. In analyses adjusted for classical risk factors and other possible covariates, both overt and subclinical HF were independently associated with increased mortality compared to no HF subjects [hazard risk ratio 1.99 (95%CI:1.02-3.91) and 3.01 (95%CI:1.90-4.78), respectively. The risk of total mortality was similar in overt and subclinical HF patients [HRR 1.30 (95%CI: 0.72-2.36)]. Within overt HF group, those with BNP >150 ng/mL had also higher mortality risk than those with low BNP levels [HRR 2.79 (95%CI: 1.67-4.68)]. The addition of left ventricle ejection fraction into definition of HF groups did not affect main results. Conclusions: Mild increase of BNP in generally stable and asymptomatic CHD patients identifies high individual mortality risk in the same extend that presence of clinically manifest HF.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV17-29520A" target="_blank" >NV17-29520A: Long term trends of CHD secondary prevention and risk prediction in selected sample of Czech population – Czech part of the EUROASPIRE V Study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACTA CARDIOLOGICA
ISSN
0001-5385
e-ISSN
1784-973X
Volume of the periodical
—
Issue of the periodical within the volume
04/2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000464422700001
EID of the result in the Scopus database
2-s2.0-85063890892