Use of Prostate Specific Antigen Density Combined with Multiparametric Magnetic Resonance Imaging Improves Triage for Prostate Biopsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000087" target="_blank" >RIV/00064190:_____/19:N0000087 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10395610 RIV/00216208:11120/19:43918233 RIV/00216208:11130/19:10395610 RIV/00064203:_____/19:10395610

Result on the web

<a href="http://dx.doi.org/10.1159/000500350" target="_blank" >http://dx.doi.org/10.1159/000500350</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000500350" target="_blank" >10.1159/000500350</a>

Result language

angličtina

Original language name

Use of Prostate Specific Antigen Density Combined with Multiparametric Magnetic Resonance Imaging Improves Triage for Prostate Biopsy

Original language description

Background: Multi-parametric magnetic resonance imaging (mpMRI)-directed biopsy for prostate cancer (PC) diagnosis improves the detection of clinically significant prostate cancer (CSPC) and decreases the rate of over-diagnosis of insignificant disease. The aim of this study was to investigate the value of mpMRI combined with prostate specific antigen density (PSAD) in the decision making related to the biopsy. Methods: mpMRI and mpMRI/transrectal ultrasound fusion targeted biopsies with subsequent systematic biopsies were performed in 397 patients (223 biopsy-naive and 174 with a previous biopsy). Detection rates of (CSPC) and insignificant PC were stratified using the PIRADS score, and the number of avoidable biopsies and missed (CSPC) were plotted against PSAD values of 0.1-0.5 ng/mL(2). Results: PIRADS <3 and PSAD <0.2 ng/mL(2) were the safest criteria for not performing a biopsy. When applied to the biopsy-naive group, 21.5% (48/223) of the biopsies could have been avoided and 3.7% (3/82) of CSPC would have been missed. In the repeat biopsy group, 12.6% (22/174) of biopsies could have been avoided and 6.9% (4/58) of (CSPC) would have been missed. Conclusions: A combination of mpMRI and PSAD might reduce the number of biopsies performed with the cost of missing <4% of CSPC.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/NV15-27047A" target="_blank" >NV15-27047A: Use of MRI with transrectal ultrasonography fusion for detecting prostate cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

UROLOGIA INTERNATIONALIS

ISSN

0042-1138

e-ISSN

1423-0399

Volume of the periodical

103

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

33-40

UT code for WoS article

000476528000005

EID of the result in the Scopus database

2-s2.0-85065618163