Chromosomal aberrations in etiology of early reproductive failure: analysis of 233 cases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000091" target="_blank" >RIV/00064190:_____/19:N0000091 - isvavai.cz</a>
Result on the web
<a href="https://www.actualgyn.com/pdf/en_2019_227.pdf" target="_blank" >https://www.actualgyn.com/pdf/en_2019_227.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Chromosomal aberrations in etiology of early reproductive failure: analysis of 233 cases
Original language description
Chromosomal aberrations are common cause of early miscarriage. Possible presence of chromosomal aberration may be assessed by cytogenetic examination of the aborted fetus tissue. In our study from the Institute of Biology and Medical Genetics of the First Faculty of Medicine of Charles University and General University Hospital in Prague we analysed tissue sample from 233 early spontaneous or missed abortions. In 212 cases the cultivation process was successful. Among those - we identified 52 cases with chromosomal aberration (24,5 %). Most common aberrations were - trisomy 21, monosomy X, triploidy and trisomies of chromosomes 16 and 22. Our overall incidence of aberrations was lower - compared to similar studies. According to other indicators we suppose that this may be caused by the higher incidence of maternal cells contamination - but this phenomenon cannot be completely excluded while using classical karyotyping. We also confirmed higher incidence of chromosomal aberrations in the miscarriage cases in elder mothers and furthermore we found higher incidence of aberrations in cases from higher gestation weeks. Both trends were statistically significant.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aktuální gynekologie a porodnictví
ISSN
1803-9588
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
2019
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
23-26
UT code for WoS article
000470753800001
EID of the result in the Scopus database
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