Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000095" target="_blank" >RIV/00064190:_____/19:N0000095 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10408635 RIV/00216208:11130/19:10408635 RIV/00064203:_____/19:10408635 RIV/26475821:_____/19:N0000004 and 2 more
Result on the web
<a href="http://dx.doi.org/10.3748/wjg.v25.i48.6939" target="_blank" >http://dx.doi.org/10.3748/wjg.v25.i48.6939</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v25.i48.6939" target="_blank" >10.3748/wjg.v25.i48.6939</a>
Alternative languages
Result language
angličtina
Original language name
Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA
Original language description
BACKGROUND One of the most notable applications for circulating tumor DNA (ctDNA) detection in peripheral blood of patients with metastatic colorectal cancer (mCRC) is a long-term postoperative follow-up. Sometimes referred to as a "liquid (re)biopsy" it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals (months or even weeks). The presence of the disease and the actual extent of the tumor burden (tumor mass) within the patient's body can be monitored. This is of particular importance, especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence. AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer. METHODS A total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers. Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling. In addition to the baseline ctDNA testing prior to surgery, a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals. The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient. RESULTS Among the monitored patients, the R0 (curative) resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures (26/28, 93%). In the remaining cases of R0 surgeries that displayed ctDNA, both patients were diagnosed with a recurrence of the disease after 6 months. In 7 patients who underwent an R1 resection, 4 ctDNA positivities (4/7, 57%) were detected after surgery and associated with the confirmation of early disease recurrence (after 3 to 7 months). All 15 patients (15/15, 100%) undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period. In 22 cases of recurrence, ctDNA positivity was detected 22 times (22/22, 100%) compared to 16 positives (16/22, 73%) by imaging methods and 15 cases (15/22, 68%) of elevated tumor markers. CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
<a href="/en/project/NV15-27939A" target="_blank" >NV15-27939A: Benefit of new "liquid biopsy" technology for monitoring of complex treatment of colorectal carcinoma in stage 3 and 4.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
WORLD JOURNAL OF GASTROENTEROLOGY
ISSN
1007-9327
e-ISSN
2219-2840
Volume of the periodical
25
Issue of the periodical within the volume
48
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
6939-6948
UT code for WoS article
000511328600007
EID of the result in the Scopus database
2-s2.0-85077304360