Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F19%3AN0000102" target="_blank" >RIV/00064190:_____/19:N0000102 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10409738
Result on the web
<a href="http://dx.doi.org/10.1111/all.13851" target="_blank" >http://dx.doi.org/10.1111/all.13851</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.13851" target="_blank" >10.1111/all.13851</a>
Alternative languages
Result language
angličtina
Original language name
Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care
Original language description
The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ALLERGY
ISSN
0105-4538
e-ISSN
1398-9995
Volume of the periodical
74
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
2293-2311
UT code for WoS article
000517148400002
EID of the result in the Scopus database
2-s2.0-85076352199