Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000022" target="_blank" >RIV/00064190:_____/21:N0000022 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10434364

Result on the web

<a href="http://dx.doi.org/10.3390/curroncol28050294" target="_blank" >http://dx.doi.org/10.3390/curroncol28050294</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/curroncol28050294" target="_blank" >10.3390/curroncol28050294</a>

Result language

angličtina

Original language name

Spontaneous Regression of Metastatic Renal Cell Carcinoma after SARS-CoV-2 Infection: A Report of Two Cases

Original language description

Spontaneous regression of metastatic renal cell carcinoma (mRCC) is a rare event, often associated with an activation of innate immunity by various triggers. SARS-CoV-2 infection induces a strong inflammatory response in some patients and a cytokine storm is one of the main causes of severe morbidity and mortality associated with the virus. Here, we describe two cases of patients with histologically and radiologically proven mRCC whose treatment was delayed due to COVID-19 and who experienced spontaneous tumour regression following the infection. Both patients reported here had predominantly pulmonary and mediastinal involvement and underwent nephrectomy. The interval between the diagnosis of COVID-19 and the detection of tumour regression was 3 and 4 months, respectively. Although approved vaccines and other measures are clearly the best way to prevent COVID-19-associated morbidity and mortality in cancer patients, we hypothesize that innate immunity activation by the infection can contribute to tumour regression in special circumstances.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CURRENT ONCOLOGY

ISSN

1198-0052

e-ISSN

1718-7729

Volume of the periodical

28

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

3403-3407

UT code for WoS article

000713301900001

EID of the result in the Scopus database

2-s2.0-85114815669