Molecular Pathology of ALS: What We Currently Know and What Important Information Is Still Missing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000044" target="_blank" >RIV/00064190:_____/21:N0000044 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921849 RIV/00216208:11110/21:10429994 RIV/00064165:_____/21:10429994 RIV/00064173:_____/21:N0000147
Result on the web
<a href="http://dx.doi.org/10.3390/diagnostics11081365" target="_blank" >http://dx.doi.org/10.3390/diagnostics11081365</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/diagnostics11081365" target="_blank" >10.3390/diagnostics11081365</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Pathology of ALS: What We Currently Know and What Important Information Is Still Missing
Original language description
Despite an early understanding of amyotrophic lateral sclerosis (ALS) as a disease affecting the motor system, including motoneurons in the motor cortex, brainstem, and spinal cord, today, many cases involving dementia and behavioral disorders are reported. Therefore, we currently divide ALS not only based on genetic predisposition into the most common sporadic variant (90% of cases) and the familial variant (10%), but also based on cognitive and/or behavioral symptoms, with five specific subgroups of clinical manifestation-ALS with cognitive impairment, ALS with behavioral impairment, ALS with combined cognitive and behavioral impairment, the fully developed behavioral variant of frontotemporal dementia in combination with ALS, and comorbid ALS and Alzheimer's disease (AD). Generally, these cases are referred to as amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD). Clinical behaviors and the presence of the same pathognomonic deposits suggest that FTLD and ALS could be a continuum of one entity. This review was designed primarily to compare neuropathological findings in different types of ALS relative to their characteristic locations as well as the immunoreactivity of the inclusions, and thus, foster a better understanding of the immunoreactivity, distribution, and morphology of the pathological deposits in relation to genetic mutations, which can be useful in specifying the final diagnosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30218 - General and internal medicine
Result continuities
Project
<a href="/en/project/NV19-04-00090" target="_blank" >NV19-04-00090: Overlap of neurodegenerative dementias and their clinic-pathological correlations: a prospective-retrospective multicentric study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DIAGNOSTICS
ISSN
2075-4418
e-ISSN
2075-4418
Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
Article Number 1365
UT code for WoS article
000688895300001
EID of the result in the Scopus database
2-s2.0-85112017018